TC_Chu's Point

Fly Over the “Brainbow”

Using a clever trick of genetic engineering, in which genes for three or more different fluorescent proteins were combined like paints to generate different hues, researchers created a system to make each neuron glow one of 100 different colors. The result was that the dendrites and axons of individual neurons, previously almost impossible to pick apart from their neighbors, could be traced through the mouse brain according to their color.

via MIT Technology Review

First Humanoid Robot in space!

via http://robots.net/article/3113.html

其實太空中已經有很多機器人 只是這隻是人形的喔

Crossed Australia powered by Kite

via core77

利用風箏來驅動橫越澳洲 基本上就是陸上行舟! 希望路上不要有太多電線桿 哈哈

European Researchers Develop World’s First Flexible Organic Microprocessor

via inhabitat

also Engadget

如果可以大量生產 我們真的可以把電腦穿在身上了

Structure variation

Structure variation consists of many kinds of variation in the genome of one species, and usually includes microscopic and submicroscopic types, such as deletions, duplications, copy-number variants, insertions, inversions and translocations. Typically a structure variation affects a sequence length about 1Kb to 3Mb, which is larger than SNPs and smaller than chromosome abnormality (though the definition have some overlapping).^[1] The definition of structural variation do not imply about the frequency or phenotypical effects. Many of struatural variants are associated with genetic diseases, however more are not. Recent research about SVs indicates that SVs are more difficult to detect than SNPs. SNPs always occur in two alleles, while approximately 5% of the human genome are defined as structurally variant in the normal population, involving more than 800 independent genes. Rapidly accumulating evidence indicates that structural variations can comprise millions of nucleotides of heterogeneity within every genome, and are likely to make an important contribution to human diversity and disease susceptibility.

http://en.wikipedia.org/wiki/Structural_variation

懷念的好滋味 軍中口糧

同事送的野戰口糧 真是懷念的好滋味 不知道為何 我就是喜歡吃這種沒調味的餅乾

Pseudo-submarine for the super rich

via Engadget

好酷ㄚ

Remote Health Detection of Elderly Person

It is a device that put on top of the stool in bathroom. It monitor the duration and how elderly use the stool , based on the data the machine will send out warning message if the data are not normal.

Haplotype

A haplotype (from the Greek: ἁπλοῦς, haploûs, "onefold, single, simple") in genetics is a combination of alleles (DNA sequences) at different places (loci) on the chromosome that are transmitted together. A haplotype may be one locus, several loci, or an entire chromosome depending on the number of recombination events that have occurred between a given set of loci.

In a second meaning, haplotype is a set of single-nucleotide polymorphisms (SNPs) on a single chromosome of a chromosome pair that are statistically associated. It is thought that these associations, and the identification of a few alleles of a haplotype block, can unambiguously identify all other polymorphic sites in its region. Such information is very valuable for investigating the genetics behind common diseases, and has been investigated in the human species by the International HapMap Project.^[1][2]

Many genetic testing companies use the term 'haplotype' to refer to an individual collection of short tandem repeat (STR) allele mutations within a genetic segment, while using the term 'haplogroup' to refer to the SNP/unique-event polymorphism (UEP) mutations which represents the clade to which a collection of potential haplotypes belong.^[3]

http://en.wikipedia.org/wiki/Haplotype

Single-nucleotide polymorphism

A single-nucleotide polymorphism (SNP, pronounced snip) is a DNA sequence variation occurring when a single nucleotide — A, T, C, or G — in the genome (or other shared sequence) differs between members of a [[biological species[[ or paired chromosomes in an individual. For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide. In this case we say that there are two alleles: C and T. Almost all common SNPs have only two alleles.

http://en.wikipedia.org/wiki/Single-nucleotide_polymorphism

Stochastic Robots Assemble and Disassemble Themselves

via IEEE Spectrum

文章名稱聽起來是很偉大 不過動作實在不怎樣 這樣簡單的動作 不是用電腦模擬比較快嗎? 當然啦東西是一步一步做出來的 只是這一步有點小 哈哈!

寧靜禱文

主啊!

求你賜我寧靜的心 去接納我所不能改變的事物

賜我無限的勇氣 去改變那有可能改變的東西

並賜我智慧 去認識這兩者的差異

每一天面對生活 享受生命的每一時刻

迎接艱難困苦 因為這是邁向和平必經之道

像上主那樣 面對這不是我們想要的罪惡世界

堅信上主會使正義彰顯 一切更新 只要我順服你的旨意

我今生得到合適的歡愉

來世與主共享永恆的快樂

---Reinhold Niebuhr (Wiki Link) (Serenity_Prayer wiki)

Farmbot

via HackADay

可愛的廚房小物

via crookedbrains

沒有Hotfile 電腦何用ㄚ(Hotfile Goes To War Against Copyright Infringers)

Hotfile, one of the rising stars on the file-hosting scene, appears to be taking a tougher stance on copyright infringement. Perhaps with an eye on the litigation recently instigated by the MPAA, this week Hotfile has been deleting premium accounts – along with all their files – en masse. Furthermore, Hotfile are reportedly not paying out the money these accounts have earned in the site’s rewards program.

http://torrentfreak.com/hotfile-goes-to-war-against-copyright-infringers-110219/

Hotfile 是一個很多人上傳資料分享的網站 裡面有很多免費的好東西 最近三四天前都被拿下架了 ㄚㄚㄚㄚㄚ

Important Micro RNA Web Sites

•Diana Lab:http://diana.cslab.ece.ntua.gr/
•miRBase:http://microrna.sanger.ac.uk/
•miRBase:http://www.mirbase.org/
•MicroCosm: http://www.ebi.ac.uk/enright-srv/microcosm/
•miRNAminer: http://groups.csail.mit.edu/pag/mirnaminer
•miRviewer: http://people.csail.mit.edu/akiezun/miRviewer
•Patrocles: http://www.patrocles.org/
•PicTar:http://pictar.mdc-berlin.de/
•TargetRank: http://hollywood.mit.edu/targetrank
•TargetScanS: http://www.targetscan.org/

via http://biochem218.stanford.edu/

MicroRNA

MicroRNAs (miRNAs) are short ribonucleic acid (RNA) molecules, on average only 22 nucleotides long and are found in all eukaryotic cells. miRNAs are post-transcriptional regulators that bind to complementary sequences on target messenger RNA transcripts (mRNAs), usually resulting in translational repression and gene silencing.^[1][2] The human genome may encode over 1000 miRNAs,^[3][4] which may target about 60% of mammalian genes^[5] and are abundant in many human cell types.^[6]

http://en.wikipedia.org/wiki/MicroRNA

Play Molecules on iPhone

via bookofjoe

外星文字? Yeast Metabolic Pathways

很像外星文字吧 這是酵母菌的所有已知代謝途徑

http://biocyc.org/intro.shtml

Systems biology

Systems biology is a term used to describe a number of trends in bioscience research, and a movement which draws on those trends. Proponents describe systems biology as a biology-based inter-disciplinary study field that focuses on complex interactions in biological systems, claiming that it uses a new perspective (holism instead of reduction). Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. An often stated ambition of systems biology is the modeling and discovery of emergent properties, properties of a system whose theoretical description is only possible using techniques which fall under the remit of systems biology.

http://en.wikipedia.org/wiki/Systems_biology

Gallery: 10 Stunning Science Visualizations

via Wire -> More works

10 個令人驚奇的科學視覺表達 (其中還是以生物學居多)

Where Does Watson Go From Here? First Stop: Healthcare

Is there an end-game here? Maybe “end-game” is too strong phrase to use, but IBM has announced a deal with Nuance Communications to “explore, develop, and commercialize the Watson computing system’s advanced analytics capabilities in the healthcare industry.”

http://www.crunchgear.com/2011/02/17/where-does-watson-go-from-here-first-stop-healthcare/

3-D Map of Fly Brain

via thebeautifulbrain

Chromatin immunoprecipitation

Chromatin Immunoprecipitation (ChIP) is a type of immunoprecipitation experimental technique used to investigate the interaction between proteins and DNA in the cell. It aims to determine whether specific proteins are associated with specific genomic regions, such as transcription factors on promoters or other DNA binding sites, and possibly defining cistromes. ChIP also aims to determine the specific location in the genome that various histone modifications are associated with, indicating the target of the histone modifiers.^[1]

http://en.wikipedia.org/wiki/Chromatin_immunoprecipitation

Arduino vending machine

via Adafruit

真棒!!!

Nerves Light Up to Warn Surgeons Away

via MIT Technology Review

就是打入一種試劑後 開刀時那些不能被切到的神經元會發出螢光告訴醫生 "不要切我 不要切我"

Japanese Inventor Akinori Ito Creates Machine That Converts Plastic Bags into Fuel

Ito’s inspiration for the method came from the simple realization that plastic bags are created from oil, thus they should be able to be converted back to their original form. The highly efficient, non-polluting machines can process polyethylene, polystyrene and polypropylene but not PET bottles, and they can convert 2 lbs. of plastic into a quart of oil using just 1 kilowatt of power. The machine heats the plastic with electricity, then traps the vapors, which it then cools and condenses into crude oil. The crude oil can be used to heat generators and some stoves, and when refined, it can be used for gasoline.

via inhabitat.com

將塑膠製品轉換成石油的機器(畢竟塑膠也是石油做的) 2磅的塑膠用1KW的電力可以產生1夸脫的石油 (1Kg to 1000cc) 這是開發給家庭用的!

夸脫

Feb. 14, 1989: GPS Enters Orbit

via adafruit

台灣出現在這本書封面上喔

via Google Books

The 8094 Control Centre.

Detail..

我也有一台 前一陣子送給同事的小孩了

The Smallest Computing Systems Yet

Traditional chips are made using a so-called top-down approach in which a design is essentially exposed like a photograph onto a semiconductor wafer, and excess material is etched away. In contrast, a bottom-up approach is used to make the nanowire circuits. This means they can be deposited on various types of surfaces, and can be made more compact. "You want [sensor] systems that are physically small," says James Klemic, nanotechnology laboratory director at MITRE. "Right now, your only option is to use a chip that dwarfs the sensor."

via MIT Technology Review

Open Letter from CEO Stephen Elop, Nokia and CEO Steve Ballmer, Microsoft

While the specific details of the deal are being worked out, here’s a quick summary of what we are working towards:

• Nokia will adopt Windows Phone as its primary smartphone strategy, innovating on top of the platform in areas such as imaging, where Nokia is a market leader.

• Nokia will help drive and define the future of Windows Phone. Nokia will contribute its expertise on hardware design, language support, and help bring Windows Phone to a larger range of price points, market segments and geographies.

• Nokia and Microsoft will closely collaborate on development, joint marketing initiatives and a shared development roadmap to align on the future evolution of mobile products.

• Bing will power Nokia’s search services across Nokia devices and services, giving customers access to Bing’s next generation search capabilities. Microsoft adCenter will provide search advertising services on Nokia’s line of devices and services.

• Nokia Maps will be a core part of Microsoft’s mapping services. For example, Maps would be integrated with Microsoft’s Bing search engine and adCenter advertising platform to form a unique local search and advertising experience.

• Nokia’s extensive operator billing agreements will make it easier for consumers to purchase Nokia Windows Phone services in countries where credit-card use is low.

• Microsoft development tools will be used to create applications to run on Nokia Windows Phones, allowing developers to easily leverage the ecosystem’s global reach.

• Microsoft will continue to invest in the development of Windows Phone and cloud services so customers can do more with their phone, across their work and personal lives.

• Nokia’s content and application store will be integrated with Microsoft Marketplace for a more compelling consumer experience.

http://conversations.nokia.com/2011/02/11/open-letter-from-ceo-stephen-elop-nokia-and-ceo-steve-ballmer-microsoft/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+NokiaConversations-Posts+%28Nokia+Conversations+-+Posts%29&utm_content=Google+Reader

ㄚ! 無論如何 當朋友還是比當敵人好 畢竟Apple and Android都太強了!

我喜歡Symbian  不過事實是我們不缺OS 我覺得就如同Desktop worl Windows/Mac/Linux 或許Mobile Wolrd 也只需要三分天下　iOS/Android/WM7 .

Other related URL

http://www.engadget.com/2011/02/11/rip-symbian/

World's first GPS-enabled goggle

via www.bookofjoe.com

Portable Rainbow Machine

via crunchgear

The Bilibot Project

http://www.bilibot.com/

A Low-Cost Robot Platform with iRobot Create, Kinect, and ROSified Computer

Fruitfly Brainbow!

Here is a compelling example of creative use of protein labeling technologies to view complex anatomy - a perfect complement to my ongoing series about fruit fly brains!

via scienceblogs.com

LEGO bunnies celebrate Chinese New Year

via Brotherbricks

The Future of the Human Genome

What will be the biggest challenge over the next five to 10 years?

At the moment, the biggest challenge is in data analysis. We can generate large amounts of data very inexpensively, but that overwhelms our capacity to understand it.

At the other end of the spectrum, we need to infuse genomic information into medical practice, which is really hard. There are issues around confidentiality, education, electronic medical records, how to carry genomic information throughout lifespan and make it available to physicians.

http://www.technologyreview.com/biomedicine/32303/?nlid=4116&a=f

OpenSCB: the open source servo controller

The goal of OpenSCB project is to create a fully open source servo controller.

It is meant to be an open source equivalent to commercial boards such as Pololu maestro, Lynxmotion SSC32 and many more. Although these boards are used by a lot of hobbyist, we believe their interfaces, softwares and capabilities could be improved by a carefully designed, open and reusable software. We based this software on an efficient hardware with several standard interfaces to make the best servo controller possible for all your projects: robots, animatronics, RC models, etc...

http://openscb.org/

Game & Watch Replica Available To Nintendo Devotees

via CrunchGear

懷念的小東西１

Wheelchair for the developing world: cheap, rugged and easy to maintain

via boingboing

DeCypher® FPGA Biocomputing Systems

DeCypher may include up to seven SeqCruncher™ FPGA devices within a
single 4U server for excellent search performance and tremendous computing density and linear performance gains. Multiple accelerated nodes with over 50 FPGA devices can be clustered for supercomputer-level performance.

http://www.timelogic.com/

Donald Norman's new book Living with Complexity

via Core77

雖然都用電子書了 但是有些書還是值得買下來

Vinculo - Arduino clone with USB slave / host capability

 

Vinculo is a 25€ development platform for the FTDI Vinculum II (VNC2) dual USB host/slave microcontroller. The board design has been copied from Arduino, and they even advertise it as Arduino-inspired and Arduino shield compatible. FTDI seems to have realized the potential that comes when having a large hobbyist userbase...

Vinculo could be called a USB-enabled Arduino, but that really doesn't do the board justice. There are many features that set it apart from the Arduino, and it also beats Arduino in all the specs (see below). Of course, it's not nearly as user-friendly as the Arduino as a first platform.

tp://embeddednewbie.blogspot.com/2011/02/vinculo-arduino-clone-with-usb-slave.html

Maxwell

http://www.showusyoursensors.com/2011/02/introducing-maxwell.html

這正是我心中想做的一款 Robot 平台 簡單但是卻有很多值得研究的地方

The Internet Just Ran Out of Numbers

On February 3, it finally happened: the clock ran out on the Internet as we know it. That was the day that the stash of Internet protocol addresses that are used to identify and locate computers connected to the Internet—the telephone numbers of the online world—was exhausted.

...

via MIT Technology Review

IPV4的地址號碼終於用光了!

把部落格搞得像蛋白質字典

真抱歉 因為這個部落格除了寫些個人觀點 也是我的讀書和網路搜尋的紀錄簿 把那些學到的蛋白質放在部落格上是為了自己日後好找 也是幫助記憶的方式 接下來的兩個月上的是有關Bioinformation 就是使用電腦程式加上對生化科學的知識用來分析 預測 甚至設計 DNA 對於細胞的代謝系統有關的科目 應該沒那麼多蛋白質資料了吧

3C

吃完年夜飯後 坐在回家的計程車上看見忠孝東路與金山高架橋間的一間賣場上有3C兩個字 心裡頭問自己3C 是哪3個C 應該是Computer , Communication ㄟ 另外一個C 是誰ㄚ 居然想不起來 而出現在腦海的另外一個3C , Command/Communication/Control 那好像是軍事上的用語吧 不會是Car , Carbon , Cargo 更不會是 Cat , CNN,Casio,Canon,..喔喔喔Camera ? 好像沒那麼狹隘 Casset,CD ? 現在已經是MP3時代 沒人看過Casset了 到底是C甚麼? Chip , Cortex-A8 , Cypress , Cyber wolrd ? 亂七八糟 !終於在快到家前想到 應該是Consumer吧 真是個無意義的字ㄚ難怪想都想不起來!

Access to Biological Literature

•Google Scholar
http://scholar.google.com/
•NLM Medline
http://www.nlm.nih.gov/pubs/factsheets/medline.html
•PubMed
http://pubmed.gov/
•PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/
•HighWire Press
http://highwire.stanford.edu/cgi/search
•Stanford University Library Searchworks
http://searchworks.stanford.edu/
•Lane Library - Ovid –Biosis – BioResearch Portal– Up-To-Date
http://lane.stanford.edu/
•EndNote
http://www.endnote.com/